Details

Project TitleClosed Head Injury Model of Rotation and Acceleration (CHIMERA)
Track Code14-070
Websitehttp://www.centreforbrainhealth.ca/wellington-cheryl
Short Description

CHIMERA is a translationally relevant platform for human traumatic brain injury (TBI) research. CHIMERA was specifically designed to overcome many of the caveats that limit the translational relevance of most existing TBI models. CHIMERA's innovation lies in its ability to generate, in a biomechanically controlled and reproducible manner, a wide range of TBI severity with completely free head movement. 

Abstract

Traumatic Brain Injury (TBI) is one of the largest unmet medical needs worldwide, with over 2M new injuries annually within North America alone with economic costs estimated at >$20 billion/year. A general need exists for pre-clinical animal models that more closely mimic the human conditions and neuropathology that follow traumatic brain injury. 

A significant challenge for translation of animal model findings to meaningful clinical use is the availability of injury models that accurately resemble the biomechanical forces that impinge on the human brain during TBI. Specifically, acceleration and rotation causing deformation and contusion of the brain within the skull accompanies many of the most common TBI incidents such as falls, motor vehicle accidents and blunt force head trauma, which is thought to result in diffuse vascular, axonal and glial damage with a complex collection of secondary manifestations that are the target of ongoing study and therapeutic development. 

The closed head injury model of engineered rotational acceleration (CHIMERA) was developed to provide an injury paradigm that is non-surgical, highly reproducible and scalable over a wide range of injury severity and CHIMERA was recently shown in mice to generate selective and diffuse white matter damage that closely resembles features of human diffuse axonal injury. 

The CHIMERA platform is intended to provide a meaningful model of diffuse axonal injury for the TBI research community that will lead to advances in basic understanding of TBI-related brain processes of degeneration and repair as well as establish a preclinical model that is more similar to the human condition so that the development of therapies may be approached with greater translational relevance. 

 
Tagsimpact, concussion, injury prevention, biomechanics, traumatic brain injury
 
Posted DateSep 21, 2017 3:00 PM

Pricing

CHIMERA (Mouse): $18,000 USD

CHIMERA (Rat): $25,000 USD

CHIMERA (Ferret): $38,000 USD

Pricing for all models includes shipping to the USA and Canada. Additional charges may apply for shipping to other regions. If you are interested in a shipping destination outside of Canada and the USA, please send us a project inquiry for more details. 

Ordering

Access to a CHIMERA device is made available by way of a non-exclusive license agreement. For further details, please contact:

Jennifer Lynett: jennifer.lynett@uilo.ubc.ca 

Investigators

Principal Inventors:

Dr. Cheryl L. Wellington and Dr. Peter A. Cripton

Publications

  1. Dhananjay R. Namjoshi, Wai Hang Cheng, Asma Bashir, Anna Wilkinson, Sophie Stukas, Kris M. Martens, TomWhyte, Zelalem A. Abebe, Kurt A. McInnes, Peter A. Cripton, Cheryl L. Wellington. 2017. Defining the biomechanical and bioloical threshold of murine mild traumatic brain injury using CHIMERA (Closed Head Impact Model of Engineered Acceleration and Rotation). Experimental Neurology, 292:80-91.
  2. Dhananjay R. Namjoshi, Wai Hang Cheng, Michael Carr, Kris M. Martens, Shahab Zareyan, Anna Wilkinson, Kurt A. McInnes, Peter A. Cripton, Cheryl L. Wellington. 2016. Chronic exposure to androgenic-anabolic steroids exacerbates axonal injury and microgliosis in the CHIMERA mouse model of repetitive concussion. PLoS One, 11(1):e0146540.
  3. Dhananjay R Namjoshi, Wai Hang Cheng, Kurt A McInnes, Kris M Martens, Michael Carr, Anna Wilkinson, Jianjia Fan, Jerome Robert, Arooj Hayat, Peter A Cripton, Cheryl L Wellington. 2014. Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury. Molecular Neurodegeneration, 9(55).
 

a place of mind, The Univeristy of British Columbia

University-Industry Liaison Office
#103 - 6190 Agronomy Road
Vancouver, BC, Canada V6T 1Z3

Tel: (604) 822-8580
Fax: (604) 822-8589
An office of the Vice-President, Research and International

    Emergency Procedures | Accessibility | Contact UBC | © Copyright The University of British Columbia