 | GLP-1 and GIP Reporter Cell Lines
Researchers
at the University of British Columbia have developed cell lines expressing the
gluc...more Researchers
at the University of British Columbia have developed cell lines expressing the
glucose-dependent insulintropic polypeptide (GIP) or glucagon-like peptide-1
(GLP-1) receptors, for diabetes and obesity research. GIP is a gut hormone with obesity-promoting
activities, and a promising drug target for obesity. GLP-1 is a gut hormone with the ability to
lower glucose levels, thus making it of great interest in developing diabetes
therapies. In the cell lines, the
activation of the GLP-1 or GIP receptor leads to cAMP production and luciferase
gene expression, enabling a bioassay of the activity of compounds targeting
these receptors. These cell lines are more sensitive than other available GIP or GLP-1
cell lines. The GLP-1 receptor cell line can detect picomolar concentrations of
activation compounds, such as GLP-1 peptides. Moreover, the GLP-1 cell line is well suited
to compound screening because it has been shown to also detect activity of
modified GLP-1 peptides and small molecule compounds. See Riedel et al., Am J Physiol Endocrinol, 2009. less | Primary: The University of British Columbia - UBC
Date posted: Apr 30, 2010 |
| CAULOBACTER S-LAYER KITS: For Recombinant Protein Secretion AND Peptide/Protein Display
A novel protein secretion and display system, using Caulobacter crescentus, that provides scalable,... moreA novel protein secretion and display system, using Caulobacter crescentus, that provides scalable, inexpensive secretion of recombinant proteins (via fusion with a C-terminal secretion signal) or display of peptides or proteins on the cell surface (via insertion into the complete S-layer gene sequence).
Caulobacter expressing the immunoglobulin G-binding domain of Streptococcal Protein G is available for purchase. less | Primary: The University of British Columbia - UBC
Date posted: Apr 12, 2010 |
| HPG-ALD Polymers for Proteomics
Novel high molecular weight dendritic hyperbranched polyglycerol-aldehydes (HPG-ALD) are availabl...more Novel high molecular weight dendritic hyperbranched polyglycerol-aldehydes (HPG-ALD) are available for purchase. HPG-ALDs can be used for selective peptide separation for mass spectrometry based proteomic analysis. less | Primary: The University of British Columbia - UBC
Date posted: Apr 7, 2010 |
| In-Source Atmospheric Pressure-Electron Capture Dissociation (AP-ECD)
A New Tool for Mass Spectrometric Analysis of Peptides and Proteins | Primary: The University of British Columbia - UBC
Date posted: Dec 2, 2009 |
| Endoglycan mAb
This antibody (F4B10) is optimized for use on FACS and live cells. It has also been validated for us... moreThis antibody (F4B10) is optimized for use on FACS and live cells. It has also been validated for use in immunoprecipitation (IP). less | Primary: The University of British Columbia - UBC
Date posted: Oct 21, 2009 |
| Protein Reagent for Enhanced Viral Transduction
Transduction reagent that improves the efficiency of viral transduction. | Primary: The University of British Columbia - UBC
Date posted: Aug 17, 2009 |
| Polymer Based Heparin Antagonists
A highly biocompatible hyperbranched polymer for the neutralization of heparin and its low molecular... moreA highly biocompatible hyperbranched polymer for the neutralization of heparin and its low molecular weight analogs. less | Primary: The University of British Columbia - UBC
Date posted: Aug 17, 2009 |
| Synthetic Substitute for Human Serum Albumin
Preparation and use of a derivatized hyperbranched polyol polymer as a substitute for serum albumin. | Primary: The University of British Columbia - UBC
Date posted: Aug 17, 2009 |
| Metabolic Modulation by Polymeric Compounds
A new use of polymeric compounds with fatty acid-binding capabilities that alters heart muscle metab... moreA new use of polymeric compounds with fatty acid-binding capabilities that alters heart muscle metabolism. less | Primary: The University of British Columbia - UBC
Date posted: Aug 17, 2009 |
| Low-Reactogenicity Whole-Cell Pertussis ( Whooping Cough ) Vaccine
Modified Bordetella pertussis strains with reduced endotoxicity, and potentially decreased reactogen... moreModified Bordetella pertussis strains with reduced endotoxicity, and potentially decreased reactogenicity as strains used for conventional whole-cell pertussis vaccines less | Primary: The University of British Columbia - UBC
Date posted: Aug 17, 2009 |